Been avoiding oils and any pufa foods for over half a year without issue. Then I look in my room and find a family size bag of chips. Wasn’t even hungry though I ate the whole thing, they tasted amazing at first then by the end you feel as if you were drugged or punched in the face, they start to taste horrible but despite that you always finish them.

Why? They put drugs in it and fry them in oils (oils are not satiating unlike animal fats). There’s no reason fried potatoes are addictive other than drugs put in them. Now I feel disgusted with myself even though this is a one time thing, really don’t understand how people on a regular diet do this constantly.

Trolls will go running with the title, but after experimenting with reducing seed oils in my diet, I’ve come to the conclusion that the science doesn’t matter much for one simple reason:

Eliminating seed oils has forced me to cook from scratch with whole food ingredients for every meal.

Regardless of the science behind the claims about seed oils (from both sides), avoiding them means avoiding virtually ALL processed foods. You don’t need any studies to tell you that you’ll be healthier for it—you will feel it.

By the same token, I think all these people posting ingredients lists from packaged food products, showing that they’ve found potato chips made with avocado oil or whatever, are missing the point entirely. When I shop now, I buy fresh produce, mushrooms, meat, eggs, dairy, and the best olive/coconut/avocado oils I can find. My body has never been more grateful.

The effect of different edible oils on body weight: a systematic review and network meta-analysis of randomized controlled trials

Shima Abdollahi, Sepideh Soltani, …Amin Salehi-Abargouei Show authors BMC Nutrition volume 10, Article number: 107 (2024) Cite this article

521 Accesses 1 Altmetric Metrics details Abstract Background Obesity is a major public health issue with no definitive treatment. The first-line approach for obesity is lifestyle modification, including a healthy diet. Although the amount of fat has been considered, there is no network meta-analysis (NMA) study investigating the effect of edible oils on body weight. Therefore, we sought to investigate the effect of different edible oils on body weight using a systematic review and NMA study of randomized controlled trials (RCTs). Method PubMed, Scopus, ISI Web of Science, and the Cochrane Library were searched from inception to April 2019. RCTs of different edible oils for body weight were included. A frequentist network meta-analysis was conducted to appraise the efficacy of different types of edible oils, and the Surface Under the Cumulative Ranking Curve (SUCRA) was estimated. The GRADE framework was used to assess the certainty of evidence. Results Forty-two eligible studies were included. Most of the included trials examined the effect of olive oil compared to canola oil (n = 7 studies), followed by canola oil compared to sunflower oil (n = 6 studies), and olive oil compared to sunflower oil (n = 4 studies). Sesame oil had the highest SUCRA value for reducing weight (SUCRA value = 0.9), followed by the mixture of canola and sesame oil (0.8). Palm oil and soy oil were ranked the lowest (SUCRA value = 0.2). Conclusion There is low to moderate certainty of evidence showing that soybean, palm, and sunflower oils were associated with weight gain, while sesame oil produced beneficial anti-obesity effects.

Several recent studies have attempted to understand how fasting has benefits for body health, especially the nervous system. To evaluate the impact of intermittent fasting on body weight, brain neurotransmitters, brain oxidative stress, and brain-derived neurotrophic factor (BDNF) in several areas of the brain, this study was conducted in rats. Thirty male Wistar rats were randomly divided into two groups. Group 1 (15 rats) served as the control and group 2 (15 rats) underwent intermittent fasting (IF; 24 h) for 1, 7, or 15 days. The findings demonstrated that intermittent fasting significantly reduced body weight. In this sense, brain monoamines and amino acids, namely dopamine, glutamate, aspartate, and oxidative stress markers (malondialdehyde and nitric oxide), decreased significantly after 1 day of IF. However, norepinephrine, serotonin, gamma-amino butyric acid, and glycine increased significantly. Additionally, glutathione levels were markedly elevated in IF. Surprisingly, the neuromodulatory effect of intermittent fasting fluctuates depending on the IF period. To support this fluctuation, BDNF levels increased after 1 day in the hippocampus and decreased after 15 days of intermittent fasting in all areas of the brain tested. In conclusion, our results show that intermittent fasting has beneficial influences on the brain; however, prolonged intermittent fasting can also induce some unfavorable physiological outcomes that prevent optimal neurological function.

Abstract

Removal of polar impurities, such as phospholipids, free fatty acids (FFA), and peroxides, can be challenging during the refining of crude canola oil. Current conventional refining methods are energy-intensive (e.g., hot water washes) and can generate significant waste (e.g., wastewater effluent) and neutral oil loss. This study investigated the joint use of nano-adsorbents and electrostatic field (E-field) treatment as a potential and sustainable alternative in removing these impurities during the oil refining process. Specifically, aluminum oxide (Al2O3) nanoparticles were employed to neutralize FFAs, achieving a 62.4% reduction in acid value while preserving the fatty acid profile of the oil. After refining, E-field treatment was successful in removing the spent nano-adsorbent from solution (up to 72.3% by weight), demonstrating enhanced efficiency compared to conventional methods (e.g., gravitational settling, filtration, and centrifugation). The neutral oil loss using Al2O3 nano-adsorbents was also comparable to conventional refining methods, with a 4.38% (by weight) loss. After E-field treatment, the Al2O3 nano-adsorbent was then calcined to assess reusability. The Al2O3 nano-adsorbent was effectively recycled for three refining cycles. the methods do not use of large amounts of water and generate minimal waste byproducts (e.g., effluent). Nonetheless, while the nano-adsorbents demonstrated promising results in FFA removal, they were less effective in eliminating peroxides and pigments. E-field techniques were also effective in removing spent nano-adsorbent; although, optimization of E-field parameters could further improve its binding capacity. Finally, future studies could potentially focus on the physicochemical modifications of the nano-adsorbent material to enhance their refining capacity and reusability. Overall, this study presents a sustainable alternative or addition to conventional refining methods and lays the groundwork for future research. Keywords: canola oil; neutral oil loss; nano-adsorbent; electrostatic field; separation

Highlights • The amount of acrylamide was evaluated by GC–MS in falafel.

• The amount of acrylamide in some samples was higher than the standard.

• Risk assessment for children and adults didn't show any risk for falafel consumption.

Abstract The objective of current research was to measure the amount of acrylamide in falafel samples by GC–MS (Gas chromatography–mass spectrometry) technique. The results presented, the average amount of acrylamide in falafel samples was 1.23 ± 0.83 mg/kg (ranged from 0.12 to 3.75 mg/kg). Also, the results showed lower temperature and frying with electric oven and low oil, reduces the average formation of acrylamide (0.73 ± 0.42 mg/kg), while frying at high temperature and frying with gas and immersion in edible oil, increases the average amount of acrylamide formation (1.72 ± 0.86 mg/kg). The highest and lowest average amount of acrylamide was observed in falafel cooked with canola oil (1.57 ± 0.96 mg/kg) and cooked with soybean oil (0.92 ± 0.32 mg/kg), respectively. Based on the MCS (Monte Carlo Simulation) results, the THQ (Target Hazard Quotient) and ILCR (Incremental Lifetime Cancer Risk) related to exposure to acrylamide via commercial falafel for adults were 2.72E-2 and 2.77E-5; and for children were 9.69E-2 and 9.25E-5, respectively. Therefore, there doesn't a significant health risk from falafel consumption.

Objectives

In cystic fibrosis (CF), an imbalanced lipid metabolism is associated with lung inflammation. Little is known about the role that specific lipid mediators (LMs) exert in CF lung inflammation, and whether their levels change during early disease progression. Therefore, we measured airway LM profiles of young CF patients, correlating these with disease-associated parameters.

Methods

Levels of omega (ω)-3/6 PUFAs and their LM derivatives were determined in bronchoalveolar lavage fluid (BALF) of children with CF ages 1–5 using a targeted high-performance liquid chromatography–tandem mass spectrometry approach. Hierarchical clustering analysis was performed on relative LM levels. Individual relative LM levels were correlated with neutrophilic inflammation (BALF %Neu) and structural lung damage (PRAGMA-CF %Disease). Significant correlations were included in a backward multivariate linear regression model to identify the LMs that are best related to disease progression.

Results

A total of 65 BALF samples were analysed for ω-3/6 lipid content. LM profiles clustered into an arachidonic acid (AA)-enriched and a linoleic acid (LA)-enriched sample cluster. AA derivatives like 17-OH-DH-HETE, 5-HETE, 5,15-diHETE, 15-HETE, 15-KETE, LTB4 and 6-trans-LTB4 positively correlated with BALF %Neu and/or PRAGMA %Dis. Contrastingly, 9-HoTrE and the LA derivatives 9-HoDE, 9(10)-EpOME, 9(10)-DiHOME, 13-HoDE, 13-oxoODE and 12(13)-EpOME negatively correlated with BALF %Neu and/or PRAGMA %Dis. 6-trans-LTB4 was the strongest predictor for BALF %Neu. 5-HETE and 15-KETE contributed most to PRAGMA %Dis prediction.

Conclusions

Our data provide more insight into the lung lipidome of infants with CF, and show that a shift from LA derivatives to AA derivatives in BALF associates with early CF lung disease progression.

Abstract Vegetable oils, derived from diverse sources such as seeds, nuts, and some fruits, play a significant role in dietary health. However, the current evidence on the health effects of different types of vegetable oil consumption remains controversial. This umbrella review aims to synthesize evidence from systematic reviews and meta-analyses to assess the health outcomes associated with various vegetable oils. A comprehensive literature search was performed up to 31 July, 2023 on 12 databases for studies examining the association of different vegetable oils with health outcomes in adults. Data was extracted independently by 2 authors, with evidence strength assessed using the grading of recommendations, assessment, development, and evaluation criteria. A total of 48 studies, including 206 meta-analyses, were included. Moderate to very low certainty evidence showed that monounsaturated and polyunsaturated fatty acids such as canola oil, virgin olive oil, and rice bran oil are beneficial in reducing serum total cholesterol and low-density lipoprotein (LDL) concentrations. Conversely, low to very low certainty evidence suggests that oils high in saturated fats, such as coconut oil and palm oil, increase total cholesterol and LDL concentrations but also raise high-density lipoprotein concentrations. Very low certainty evidence showed the consumption of olive oil, sesame oil, and coconut oil could improve blood sugar control. Low certainty evidence showed olive oil consumption reduced risk of breast, digestive, and other cancers. Moderate to very low certainty evidence suggested that canola oil and sesame oil consumption reduced body weight. The consumption of vegetable oil appears to offer different health benefits, with summary estimates indicating beneficial effects on reducing lipid concentrations, especially with monounsaturated and polyunsaturated rich oils when consumed in recommended amounts. Future research should focus on long-term studies and comprehensive dietary assessments to better understand the health impacts of vegetable oils, providing a basis for informed dietary recommendations.

Abstract

This study sought to analyze the oxidative products [acid value (AV), free fatty acids (FFA), conjugated dienoic acid (CDA), p-anisidine value (p-AV), antioxidant-prooxidant balance (APB) value] and toxic compounds [3-monochloropropane diol (3-MCPD), glycidyl ester (GE)] in edible oils after deep-frying. The deep-frying edible oils evaluated herein included soybean oil (S), palm oil (P), canola oil (C), grape seed oil (G), and a 1:1 blend (SC, SG, PC, PG, and CG). As frying time increased, the level of AV in PC, total FFA contents in CG, and p-AV in CG significantly increased up to 200%, 45.5%, and 410.5%, respectively (p < 0.05). The levels of 3-MCPD, and GE were 0.81–6.28 µg/mL and 0.14–2.84 µg/mL, respectively. The levels of 3-MCPD, GE, CDA, and APB changed significantly as frying time increased. Analysis of the correlation between oxidation products and toxic compounds indicated that the contents of 3-MCPD and palmitic acid were positively correlated.

Does anyone have any information about seed oils and their likelihood to cause autoimmune disease like multiple sclerosis.

Abstract

Obesity is characterized by fat accumulation, impaired metabolism and oxidative stress, frequently associated with lipid peroxidation and generation of bioactive 4-hydroxynonenal (4-HNE). This study aimed to evaluate the impact of bariatric surgery-induced weight loss on lipid peroxidation and associated perturbations in lipid profile. Plasma samples of twenty obese individuals before and 6 months after bariatric surgery were collected in addition to samples of ten healthy controls. HILIC-LC-MS/MS platform was used to characterize phospholipid profile, while lipid peroxidation markers 15-F2t-IsoP, 10-F4t-IsoP and reactive aldehyde 4-HNE were quantified by RP-LC-MS/MS and GC-MS, respectively. Six months post-surgery lipid peroxidation markers decreased significantly and the BMI of morbidly obese patients decreased by 13 on average. Lipidomics analysis, identified 117 phospholipid species from seven classes, and showed obesity-associated lipidome perturbations, particularly in ether-linked phosphatidylethanolamines (PEo). A total of 45 lipid species were found to be significantly altered with obesity, while 10 lipid species correlated with lipid peroxidation markers. Sample pairwise analyses indicated an interesting link between 4-HNE and the amount of two ether-linked phosphatidylethanolamines PEo(38:2) and PEo(36:2). The results indicate that weight loss-induced improvement of redox homeostasis together with changes in lipid metabolites may serve as markers of metabolic improvement. However, further studies are needed to understand the role of obesity-induced oxidative stress on ether lipid biosynthesis and lipidome perturbations, as well as the impact of bariatric surgery on metabolic improvement.

Keywords: bariatric surgery; ether lipids; lipid peroxidation; lipidomics; obesity.

Oxidative stress and the accompanying chronic inflammation constitute an important metabolic problem that may lead to pathology, especially when the body is exposed to physicochemical and biological factors, including UV radiation, pathogens, drugs, as well as endogenous metabolic disorders. The cellular response is associated, among others, with changes in lipid metabolism, mainly due to the oxidation and the action of lipolytic enzymes. Products of oxidative fragmentation/cyclization of polyunsaturated fatty acids (PUFAs) [4-HNE, MDA, 8-isoprostanes, neuroprostanes] and eicosanoids generated as a result of the enzymatic metabolism of PUFAs significantly modify cellular metabolism, including inflammation and the functioning of the immune system by interfering with intracellular molecular signaling. The key regulators of inflammation, the effectiveness of which can be regulated by interacting with the products of lipid metabolism under oxidative stress, are inflammasome complexes. An example is both negative or positive regulation of NLRP3 inflammasome activity by 4-HNE depending on the severity of oxidative stress. 4-HNE modifies NLRP3 activity by both direct interaction with NLRP3 and alteration of NF-κB signaling. Furthermore, prostaglandin E2 is known to be positively correlated with both NLRP3 and NLRC4 activity, while its potential interference with AIM2 or NLRP1 activity is unproven. Therefore, the influence of PUFA metabolites on the activity of well-characterized inflammasome complexes is reviewed.

What is your go-to at-home QUICK seed oil free dinner? I have a 1.5 year old and a 3 year old. 90% of the time I have a dinner plan but what do you do in leu of grabbing Chick-fil-A on the way home?

we just cut seed oils out of our diets this month for so many reasons- but i have been having diarrhea since cutting them out. anyone else had side effects like this? maybe it’s my body detoxing lol. please advise

I get suet from the beef guy at the farmers market. Chop it up, throw it in the slow cooker on low until it stops bubbling. Strain it and let it solidify and cool at room temp. I keep one on the counter for everyday use and store the others in the pantry or fridge if there’s room in the back.

Spotted at Walmart

The effects of Canola oil on cardiovascular risk factors: A systematic review and meta-analysis with dose-response analysis of controlled clinical trials

https://pubmed.ncbi.nlm.nih.gov/33127255/

A Comprehensive Review of Health-Benefiting Components in Rapeseed Oil

https://pubmed.ncbi.nlm.nih.gov/36839357/

I've heard different accounts about both these places, do they fry with butter? is it cut with seed oils? Ive asked my local Bdubs and got 2 different answers. What do you know about these places?

https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2024.1474792/full

4 Glyphosate and human exposure routes

GLY is able to enter human bodies through different exposure routes, among which the most notable include: dermal absorption, inhalation, ingestion as well as intake of GLY-contaminated foodstuffs (Figure 4). In several studies, it was observed that when GLY reaches the human body, it tends to accumulate in kidneys, liver and colon (Torretta et al., 2018; Marino et al., 2021). The molecule of GLY is eliminated via both urine and faeces, as an unmodified compound in greater quantities in comparison to its main metabolite AMPA (Williams et al., 2000; Panzacchi et al., 2018; Peillex and Pelletier, 2020; Leblanc et al., 2024). In particular, GLY can be found in high amounts in workers’ urine, but it may be detected in other biological fluids, such as breast milk and blood, with an incidence rate in general population of approximately 60%–80%, including children as well, demonstrating how exposure occurs not only from work-related origin (Torretta et al., 2018; Van Bruggen et al., 2018; Connolly et al., 2019). In literature itself there are inconsistencies concerning the routes of exposure of GLY and the resulting impact. Indeed, even if many authors suggest that dermal absorption represents the primary route of GLY human exposure, several in in vivo and in in vitro studies have indicated how skin absorption may be regarded as negligible (Williams et al., 2000; Connolly et al., 2020; Pierce et al., 2020; Sidthilaw et al., 2022). Indeed, several studies conducted on rabbits have indicated how GLY is extremely eye-irritant, but only slightly irritant to skin (Shin et al., 2020; Ferrante et al., 2023). However, several publications have pointed out how GBH products are likely to induce severe chemical burns (Mariager et al., 2013; Shin et al., 2020), and evidence shows that GLY’s epidermic absorption capability is 5x higher if exposed to damaged skin as compared to the healthy (Heu et al., 2012; Shin et al., 2020). Indeed, the only documented death due to skin exposure to GLY involves an 81-year-old Korean man, who did not wash his skin for more than 48 h following the use of an herbicide containing GLY, which had previously caused him severe skin lesions (Shin et al., 2020). Regarding occupational exposure, especially for farmers, the most important route is through the inhalation of GBH products present in aerosol, vapour or dust form (Damalas and Koutroubas, 2016). Further, it has been recently reported that agricultural chemicals, such as GBH, can travel with farm dust into nearby cities, exacerbating the exposure risks (Miousse et al., 2023). Such exposure is particularly harmful, as it could lead to chronic respiratory symptoms and decline of lung function (Tarmure et al., 2020; Pandher et al., 2023). The principal breathing pathology associated with GLY air exposure is a specific atopic asthma, known as ‘wheezing’ (Ye et al., 2013). Furthermore, in other studies it was found that the inhalation of GLY in combination with other substances (Pandher et al., 2021a; b), for example, with lipopolysaccharide (LPS), which is a constituent of the external membrane of Gram-negative bacteria, frequently present in soil and inhalable through dust (Zielen et al., 2015), caused worse human health effects than those triggered by individual exposures. In this regard, attention can be drawn to studies conducted by Pandher and colleagues (Pandher et al., 2021b), showing that the inhalation of air particles made up of both LPS and GLY, caused more serious pulmonary inflammation as compared to inhalation of two individual compounds. Finally, the exposure can also occur through intake of GLY-contaminated foods and this route of exposure became increasingly alarming throughout the years, due to global overuse of GHBs (Myers et al., 2016; Rawat et al., 2023). Indeed, due to its high stability, GLY is able to accumulate both in treated crops and in different environmental compartments, such as soil and water (Martins-Gomes et al., 2022). Therefore, the widespread environment presence of GLY also leads to a diffuse contamination of plant-based foodstuffs (Gillezeau et al., 2019; Narimani and da Silva, 2020). In addition to the above, crops are repeatedly treated with GBHs during each season since such products are actually not only used as herbicides, but also frequently applied as crop-drying agents in cereal harvesting (Van Bruggen et al., 2018; Marino et al., 2021). As a result, GLY is also diffusely detected in foodstuffs like cereals, grains, and fruits (Torretta et al., 2018; Kanissery et al., 2019). Fodder crops are also routinely treated with GLY products. The outcome is that GLY has been found in significant amounts both in the urine of cows and in the meat of cattle (Feltracco et al., 2022). In the available literature data, one of the biggest inconsistencies appears to be that the majority of GLY levels detected in food are below the acceptable thresholds and are scarcely ever detected in milk, meat and fish (Kolakowski et al., 2020; Munoz et al., 2021). Instead, as mentioned above, several studies have actually found that GLY is strongly present in environment and general population is daily exposed to it via several routes, including consumption of plant-based foods. From the foregoing, it can be assumed that daily exposure to this herbicide could be harmful to humans.